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1 History of Use and Potential Sources
1. History of Use and Potential Sources
1.1 History of 1,4-Dioxane Production
1.2 Uses of 1,4-Dioxane
1.3 Primary and Secondary Sources of Contamination
1.4 Presence in Environmental Media
2 Regulatory Framework
2. Regulatory Framework
2.1 Federal Regulation of 1,4-Dioxane
2.2 State Regulation of 1,4-Dioxane
2.3 International Regulation
3 Environmental Fate, Transport, and Investigative Strategies
3. Environmental Fate, Transport, and Investigative Strategies
3.1 Chemical and Physical Properties
3.2 Considerations for Developing or Refining a CSM for 1,4-Dioxane
4. Sampling and Analysis
4. Sampling and Analysis
4.1 1,4-Dioxane Sampling
4.2 1,4-Dioxane Analysis
4.3 1,4-Dioxane Data Evaluation
5. Toxicity and Risk Assessment
5. Toxicity and Risk Assessment
5.1 Human Exposure Assessment
5.2 Human Toxicity
5.3 Ecological Exposure and Toxicity
5.4 Risk Characterization and Uncertainty
5.5 Risk Communication
6. Remediation and Treatment Technologies
6. Remediation and Treatment Technologies
6.1 Characteristics That Affect Treatment Selection
6.2 Drinking Water and Wastewater Treatment
6.3 Soil/Vadose Zone Treatment
6.4 Ex Situ Groundwater Treatment
6.5 In Situ Groundwater Treatment
Case Studies
Fact Sheets
References
Appendix A: Summary of State Regulations, Policies, and Guidance for 1,4-Dioxane
Appendix B: 1,4-Dioxane Identifiers and the Physical and Chemical Properties of 1,4-Dioxane
Appendix C: Additional Information Regarding 1,4-Dioxane Cancer Toxicity Values
Appendix D: Team Contacts
Appendix E: Glossary
Appendix F: Acronyms
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Appendix C: Additional Information Regarding 1,4-Dioxane Cancer Toxicity Values

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